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Primary lymphoma of the brain

 

Definition

Primary lymphoma of the brain is cancer of the lymph cells that starts in the brain.

Alternative Names

Brain lymphoma; Cerebral lymphoma; Primary lymphoma of the central nervous system; Lymphoma - brain

Causes

The cause of primary brain lymphoma is unknown. It is more common in people ages 45 - 70.

Patients who have a weakened immune system are at greater risk for primary lymphoma of the brain. Common causes of a weakened immune system include:

  • HIV
  • Organ transplants (especially heart transplants)

Primary lymphoma of the brain is also linked to Epstein-Barr Virus (EBV) infection, the virus that causes mononucleosis.

The rate of primary brain lymphoma is rising, but it is still relatively rare.

Symptoms
Signs and tests

The following tests may be performed to help diagnose a primary lymphoma of the brain:

Support Groups

Expectations (prognosis)

The survival of untreated primary brain lymphoma is under 2 months. Treated with chemotherapy, patients often survive 3 - 4 years or more. About 40% of patients are alive at 5 years. In general, older patients have a worse outlook than younger patients.

Calling your health care provider

Complications

Possible complications include:

  • Chemotherapy side effects, including low blood counts
  • Radiation side effects, including confusion, headaches, nervous system (neurologic) problems, and tissue death
  • Return (recurrence) of the lymphoma
Treatments

The condition is usually first treated with corticosteroids to control any local swelling and improve symptoms. However, chemotherapy may increase survival by 3 - 4 years, or longer. The chemotherapy is usually high doses of methotrexate given through a vein (intravenously) or a spinal tap (intrathecally).

Treating patients with weakened immune systems is not as successful, but it is improving.

Radiation therapy used to be the main treatment for primary lymphoma of the brain. Now it is usually reserved for treating patients who do not respond to chemotherapy.

Treatment with multiple therapies (combination therapy) is common.

Prevention

References

DeAngelis LM. Tumors of the central nervous system and intracranial hypertension and hypotension. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 199.

National Cancer Institute. Primary CNS lymphoma treatment (PDQ). 2009. Accessed February 25, 2009.


Review Date: 3/2/2010
Reviewed By: David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc., and Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital.
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