Reye syndrome is sudden (acute) brain damage (encephalopathy) and liver function problems of unknown cause.
The syndrome has occurred with the use of aspirin to treat chickenpox or the flu in children. However, it has become very uncommon since aspirin is no longer recommended for routine use in children.
Reye syndrome is most often seen in children ages 4 - 12. Most cases that occur with chickenpox are in children ages 5 - 9. Cases that occur with the flu (influenzae type B) are usually in children ages 10 - 14.
Children with Reye syndrome get sick very suddenly. Reye syndrome usually follows an upper respiratory infection (URI) or chickenpox by about 1 week.
Reye syndrome often begins with vomiting, which lasts for many hours. The vomiting is quickly followed by irritable and aggressive behavior. As the condition gets worse, the child may be unable to stay awake and alert.
Other symptoms of Reye syndrome:
- Loss of consciousness or coma
- Mental changes
- Nausea and vomiting
- Unusual placement of arms and legs (decerebrate posture) -- the arms are extended straight and turned toward the body, the legs are held straight, and the toes are pointed downward
Other symptoms that can occur with this disorder include:
The following tests may be used to diagnose Reye syndrome:
How well a person does depends on the severity of any coma, as well as other factors.
The outcome for those who survive an acute episode may be good.
Go to the emergency room or call the local emergency number (such as 911) immediately if your child has confusion, lethargy, or other mental changes.
Untreated, seizures and coma may be life-threatening.
There is no specific treatment for this condition. The health care provider will monitor the pressure in the brain, blood gases, and blood acid-base balance (pH).
Treatments may include:
- Breathing support (a breathing machine may be needed during a deep coma)
- Fluids by IV to provide electrolytes and glucose
- Steroids to reduce swelling in the brain
Never give a child aspirin unless told to do so by your doctor.
When a child must take aspirin, take care to reduce the child's risk of catching a viral illness such as the flu and chickenpox. Avoid aspirin for several weeks after the child has received a varicella (chickenpox) vaccine.
Note: Other over-the-counter medications, such as Pepto-Bismol and substances with oil of wintergreen also contain aspirin compounds called salicylates. Do not give these to a child who has a cold or fever.
Cohen J, Powderly WG. Infectious Diseases. 2nd ed. New York, NY: Elsevier; 2004:310-311.
Goetz, CG. Textbook of Clinical Neurology. 2nd ed. St. Louis, Mo: WB Saunders; 2003: 656-657.
Ferri FF. Ferri’s Clinical Advisor: Instant Diagnosis and Treatment. 2005 ed. St. Louis, Mo: Mosby; 2005:738.
Noble J. Textbook of Primary Care Medicine. 3rd ed. St. Louis, Mo: Mosby; 2001:46-47.
Michaels MG. Rye Syndrome. In: Long SS, Pickering LK, Prober CG, eds. Principles and Practice of Pediatric Infectious Diseases. 2nd ed. Philadelphia, Pa:Churchill Livingstone; 2003:chap 50.
Review Date: 8/1/2008
Reviewed By: Neil K. Kaneshiro, MD, MHA, Clinical Assistant Professor of Pediatrics, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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